Laboratory of Structural & Supramolecular Chemistry

Research Projects


References: B.  Synthesis of functional cyclodextrin derivatives and applications


1. K. Eliadou, P. Giastas, K. Yannakopoulou, I. M. MavridisSynthesis of 6-Mono-6-deoxy-β-cyclodextrins substituted with isomeric aminobenzoic acids. Structural Characterization, Conformational Preferences and Self-inclusion, as Studied by NMR Spectroscopy in Aqueous Solution, and by X-Ray Crystallography in the Solid State”, J. Org. Chem. 2003, 68, 8550-8557.

 2. P. Giastas, K. Eliadou, Z. F. Plyta, K. Yannakopoulou, and I. M. MavridisStructural Characterization of Per-6-bromo-2,3-di-O-acetyl-β-cyclodextrin, Studied in Solution by NMR Spectroscopy and in the Solid State as a Methanol Complex by X-Ray Crystallography. Unsusual glucopyranose conformations in the crystal” Carbohydr. Res., 2004, 339, 1189-1194.

 3. A. Paulidou, P. Giastas, N. Mourtzis, K. Yannakopoulou, I. M. Mavridis “Crystal and Molecular Structure of Octakis(6-bromo-6-deoxy)-γ-cyclodextrin. A novel stacking of a distorted macrocycle”, Carbohydr. Res., 2007, 342, 1519-1524.

 4. D. Maffeo, L. Leondiadis, I. M. Mavridis, K. Yannakopoulou, “Positive Effect of Natural and Negatively Charged Cyclodextrins on the Stabilization of Penicillins towards β-Lactamase Degradation due to Inclusion and External Guest-Host Association. An NMR and MS Study”, Org. Biomolec. Chem. 2006, 4 (7), 1297-1304.

 5. N. Mourtzis, K. Eliadou, K. Yannakopoulou "Influence of Host’s Substitution on the Orientation of the Guest: Pseudo-rotaxanes of Charged Cyclo­dextrins with Methyl Orange in Solution.” N. Mourtzis, K. Eliadou, K. Yannakopoulou, Supramolecular Chem. 2004,16 (8), 587–593.

 6. N. Mourtzis, K. Eliadou, C. Aggelidou, V. Sophianopoulou, I. M. Mavridis, K. Yannakopoulou, “Synthesis and characterization of per(6-guanidino-6-deoxy)cyclodextrins and studies of their  effect on DNA”, Org. Biomol. Chem. 2007, 5, 125-131.

 7. N. Mourtzis, M. Paravatou, I. M. Mavridis, M. L. Roberts, K. Yannakopoulou Synthesis, characterisation, and remarkable biological properties of cyclodextrins bearing guanidino-alkylamino and aminoalkylamino groups on their primary side”, Chem.Eur. J. 2008, 14, 4188-4200.

 8. K. Yannakopoulou, L. Jicsinszky, C. Aggelidou, N. Mourtzis, T. M. Robinson, A. Yohannes, E. M. Nestorovich, S. Bezrukov4, V. A. Karginov “Symmetry requirements for the effective blocking of pore-forming toxins: Comparative study with α-, β-, and γ-cyclodextrin derivatives”,  Antimicrob. Agents Chemother. (AAC), 2011, 55, 3594-3597.

 9.  K. Yannakopoulou Cationic Cyclodextrins: Cell Penetrating Agents and Other Diverse Applications”, J. Drug Del. Sci. Tech., 2012, 22, 243-249 (review article).

10. D. Maffeo, M. Lampropoulou, M. Fardis, Y. G. Lazarou, I. M. Mavridis, D. A.I. Mavridou, E. Urso, H. Pratsinis, D. Kletsas, K. Yannakopoulou, “Novel Polycarboxylated EDTA-Type Cyclodextrins as Ligands for Lanthanide Binding: Study of Their Luminescence, Relaxivity Properties of Gd(III) Complexes, and PM3 Theoretical Calculations”, Org. Biomol. Chem. 2010, 8, 1910-1921.

11. M. Lampropoulou, K. Yannakopoulou “Synthesis and characterisation of novel glycoclusters based on cell penetrating heptakis(6-aminoethylamino-6-deoxy)-β-cyclodextrin”, J. Incl. Phen. Macrocycl. Chem, 2011,70, 345-352.

12. D. Maffeo, Z. Velkov, K. Misiakos, K. Mergia,  A. Paulidou, M. Zavali, I. M. Mavridis, K. Yannakopoulou “Real Time Monitoring of Nanomolar Binding To a Cyclodextrin Monolayer Immobilised on a Si/SiO2/Novolac Surface Using White Light Reflectance Spectroscopy: The Case of Triclosan”, J. Colloid. Interface Sci. 2011, 358, 369–375.

 13.   L. E. P. Kyllönen, V. Chinuswamy, D. Maffeo, E..T. Kefalas, J. M. Haider, Z. Pikramenou, I. M. Mavridis,  K. Yannakopoulou,   N. Glezos “Electronic transport between Au surface and STM tip via a multipodal cyclodextrin host - metallo-guest supramolecular system” , J. Phys. Org. Chem. 2012,  25, 198206.

14. A. Fraix, Antonio R. L. Gonçalves, V. Cardile, A. C. E. Graziano, T. A. Theodossiou, K. Yannakopoulou and S. Sortino "A Multifunctional Bichromophoric Nanoaggregate for Fluorescence Imaging and Simultaneous Photogeneration of RNOS and ROS”, Chem. Asian J. 2013, 8, 2634-2641.

15. C. Aggelidou, T. A. Theodossiou, K. Yannakopoulou "Protoporphyrin IX-β-Cyclodextrin Bimodal Conjugate: Nanosized Drug Transporter and Potent Phototoxin", Photochem. Photobiol., 2013, 89, 1011-1019.

16. L. Piras, T. A. Theodossiou, M. D. Manouilidou, S. Sortino, K. Yannakopoulou "S-Nitroso-β-Cyclodextrins as Novel Bimodal Carriers: Preparation, Detailed Characterization, Nitric Oxide Release and Molecular Encapsulation", Chem. Asian J. 2013, 8(11), 2768-2778.

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