Laboratory of Structural & Supramolecular Chemistry

Dr. Konstantina Yannakopoulou


Konstantina Yannakopoulou graduated from the Chemistry Department, University of Athens. She earned a research scholarship in Nuclear Research Center “Demokritos” where she stayed for two semesters (1982) and then she moved to South Carolina, US, where she earned a MS degree in Chemistry with Prof. R. A. Abramovitch at Clemson University (1985) entitled “Remote Intramolecular Functionalization of Arylnitrenium Ions. Seven-membered Ring Formation”. She obtained her PhD degree in Chemistry with Prof. A. R. Katritzky at the University of Florida (1988) on “N-(α-Aminoalkyl)benzotriazoles: Equilibria and Reactions”. After an eight-month post-doctoral stay at the same laboratory she joined the Institute of Physical Chemistry, National Center for Scientific Research “Demokritos” in 1989, also as a post-doc. In 1996 she became a staff-member and in 2006 she became Researcher A and since Oct. 2011 is in charge of the Laboratory of Structural and Supramolecular Chemistry. Her research interests focus on molecular structure-properties relations and particularly on the characterization of host/guest interactions, stability and equilibria of cyclodextrin-guest systems, synthetic modifications of cyclodextrins to functional host molecules and their biological applications. She has authored and co-authored over 52 papers, and presented her work in more than 46 conference publications.




1. "Remote Intramolecular Functionalization of Arylnitrenium Ions. Seven-membered Ring Formation», K. Yannakopoulou, Master’s thesis, March 1985, Chemistry Department, Clemson University, Clemson, SC, USA.

2. “N-(α-Aminoalkyl)benzotriazoles: Equillibria and Reactions” K. Yannakopoulou, PhD Dissertation, October 1988, University of Florida, FL, USA.

Publications in Peer-review Journal

  1. "Remote Intramolecular Functionalization of Arylnitrenium Ions. Seven-membered Ring Formation" R. A. Abramovitch,* R. Jeyaraman, K. Yannakopoulou, J. Chem. Soc. Chem. Commun. 1985, 1107.

  2. "2-Pyrazinyl-2-arylalkanenitriles" A. R. Katritzky,* K. Yannakopoulou, J. Thomson, F. Saczewski, B. Pilarski, J. Chem. Engr. Data, 1987, 32, 479.

  3. "The Chemistry of N-Substituted Benzotriazoles. Part 7.  The Isomeric Composition and Mechanism of Interconversion of Some N-(Aminomethyl)-benzotriazole Derivatives" A. R. Katritzky,* K. Yannakopoulou,  W. Kuzmierkiewicz, J. Aurrecoechea, A. E. Koziol, G. J. Palenik, M. Sczesniak, R. Skarjune,  J. Chem. Soc. Perkin Trans. 1, 1987, 2673.

  4. "The Chemistry of N-Substituted Benzotriazoles. Part 14. Novel Routes to Secondary and Tertiary Amines and to N,N-Disubstituted  Hydroxylamines" A. R. Katritzky,* K. Yannakopoulou, P. Lue, D. Rasala, L. Urogdi, J. Chem. Soc. Perkin Trans. I, 1989, 225.

  5. "A General Method for the Preparation of β-Aminoesters" A. R. Katritzky,* K. Yannakopoulou,  Synthesis, 1989,  747.

  6. "A New General Method for the Synthesis of Tertiary Propargylamines (N,N-Dialkyl-2-alkynamines" A. R. Katritzky,* J. K.  Gallos, K. Yannakopoulou, Synthesis, 1989, 31.          

  7. "The Chemistry of N-Substituted Benzotriazoles. Part 18. A Study of the Influence of Structure on the 1- to 2-(N,N-Dialkylaminoalkyl)-benzotriazole Equilibrium" A. R. Katritzky,* K. Yannakopoulou, Heterocycles,  1989, 28, 1121.

  8. "Benzotriazol-1-ylmethyl Isocyanide, a New Synthon for CH-N=C Transfer. Syntheses of α-Hydroxyaldehydes, 4-ethoxyoxazolines and Oxazoles" A. R. Katritzky,* Y.-X. Chen, K. Yannakopoulou, P. Lue, Tetrahedron Lett. 1989, 30, 6657.

  9. "Synthesis of 3(5)-Substituted 1,2,4-Triazoles by Lithiation of 1-(1-Pyrrolidinomethyl)-1,2,4-Triazole", A. R. Katritzky,*  P. Lue, K. Yannakopoulou, Tetrahedron, 1990, 46, 641.

  10. "Isomerizations of N-(α-Aminoalkyl)-1,2,4-triazoles and N-(α-Aminoalkyl)tetrazoles", A. R. Katritzky,* A. Joswiak, P. Lue, K. Yannakopoulou, G. J. Palenik, Z. Zhang, Tetrahedron,  1990, 46, 633.

  11. "Influence of Structure on the Isomerization of  Dialkylaminoalkylbenzotriazoles" A. R. Katritzky,* A. Joswiak, F. Saczewski, K. Yannakopoulou,  J. Phys. Org. Chem. 1990, 3, 289.

  12. "Ab Initio and Semiempirical Calculations on the Tautomeric Equilibria of N-Unsubstituted and N-Substituted Benzotriazoles" A. R. Katritzky,* K. Yannakopoulou, E. Anders, J. Stevens, M. Szafran,  J. Org. Chem. 1990, 55, 5683.

  13. 13.          "New Synthesis of Amines and Amides Mediated by Additions of Benzotriazole to Enamines and Enamides and Transformastions of the Adducts", A. R. Katritzky,* S. Jurczyk, B. Rachwal,  S. Rachwal, I. Shcherbakova, K. Yannakopoulou, Synthesis, 1992, 1295.        

  14. "Inclusion Complexes of Cyclomaltoheptaose (β-cyclodextrin) and its Methylated Derivatives with the Main Components of the Pheromone of the Olive Fruit Fly", A. Botsi, K. Yannakopoulou,* E. Hadjoudis, Carbohydr. Res. 1993, 241, 37.

  15. "NMR Differentiation of Enantiomeric (+)- and (-)-α-Pinene via Complexation with Cyclodextrins in Water" A. Botsi, K. Yannakopoulou,* E. Hadjoudis and B. Perly,  J. Chem. Soc. Chem. Commun. 1993, 1085.

  16. “The ionization and Conductivity of N-(aminoalkyl)benzotriazoles in nitromethane” A. R. Katritzky,* K. Yannakopoulou, P. Barczynski, M. Szafran, M.M. Karelson, Org. React. (Tartu) 1993, 28(1), 92-5.

  17. "Characterization of a Positive-tone wet Silylation Process with the AZ 5214TM Photoresist" E. Gogolides,* K. Yannakopoulou, A. Traverse, A. G. Nassiopoulos, E. Tsoi, M. Hatzakis,  Microelectronic Engineering, 1994, 25, 75-90.

  18. "Lithographic Evaluation of a New Wet Silylation Process Using Safe Solvents and the Commercial Photoresist AZ 52314 TM", E. Gogolides,* K. H. Baik, K. Yannakopoulou, L. Van den hove, M. Hatzakis,  Microelectronic Engineering,  1994, 23, 267.

  19. "Aminal Exchange" A. R. Katritzky,* K. Υannakopoulou, H. Lang, J. Chem. Soc. Perkin Trans. 2,  1994, 1867.

  20. "The Mesomorphic Behaviour of Cyanopropylalkyldimethylammonium Bromides", M. Arkas, K. Yannakopoulou, C. M. Paleos,* P. Weber and A. Skoulios,  Liq. Cryst. 1995, 18, 563.

  21. "Positive or Adverse Effects of Methylation on the Inclusion Behaviour of Cyclodextrins. A Comparative NMR Study Using Pheromone Constituents of the Olive Fruit Fly", A. Botsi, K. Yannakopoulou,* B. Perly and E. Hadjoudis, J. Org. Chem., 1995, 60, 4017.

  22. "Structural Aspects of Permethylated Cyclodextrins and Comparison to their Parent Oligosaccharides, as Derived from Unequivocally Assigned 1H and 13C NMR Spectra in Aqueous Solutions" A. Botsi, K. Yannakopoulou,* B. Perly and E. Hadjoudis, Magn. Reson. Chem. 1996, 34, 419-423.

  23. "AM1 Calculations on Inclusion Complexes of Cyclomaltoheptaose (β-Cyclodextrin) with 1,7-Dioxaspiro[5.5]undecane and Nonanal, and Comparison with Experimental Results." A. Botsi, K. Yannakopoulou,*  E. Hadjoudis, and J. Waite, Carbohydr. Res., 1996, 283, 1-16.

  24. Chiral Recognition of (R)-(-)-1,7-Dioxaspiro­[5.5]­un­decane by Hexa­­kis(2,3,6-tri-O-methyl)-α-Cyclodextrin”. K. Yannakopoulou, D. Mentzafos, I. M. Mavridis,* K. Dandika, Angew. Chem. Int. Ed. Engl. 1996, 35, 2480-2482.

  25. “Organization of Long Aliphatic Monocarboxylic Acids in β-Cyclodextrin Channels” S. Makedonopoulou, I. M. Mavridis,* K. Yannakopoulou, J. Papaioannou, J. Chem. Soc. Chem. Commun.,1998, 2133.

  26. “Structure of the 1:1 complex of hexakis(2,3,6-tri-O-methyl)-α-Cyclodextrin with (R)-(-)-1,7-Dioxaspiro[5.5]­undecane”, D. Mentzafos, I. M. Mavridis* and K. Yannakopoulou, J. Incl. Phenom. Macrocyclic Chem., 1999, 33, 321-330.

  27. NMR Detection of Simultaneous Formation of [2]- and [3]Pseudorotaxanes in Aqueous Solution between α-Cyclodextrin and Linear Aliphatic α,ω-Aminoacids, an α,ω-Diamine and an α,ω-Diacid of Similar Length, and Comparison with The Solid State Structures” K. Eliadou, K. Yannakopoulou,* A. Rontoyianni, I.M. Mavridis, J. Org. Chem. 1999, 64, 6217-6226.

  28. “Clay Polyvinyl pyridine nanocomposites” K.G. Fournaris, M.A. Karakassides, D. Petridis* and K. Yannakopoulou, Chemistry of Materials, 1999, 11, 2372-2381.

  29. “Non-covalent interactions in the crystallization of enantiomers of 1,7-dioxaspiro[5.5]undecane (olive fly sex pheromone) by enantiospecific cyclodextrin hosts, hexakis(2,3,6-tri-O-methyl)-α-cyclodextrin and heptakis(2,36-tri-O-methyl)-β-cyclo­dextrin”. S. Makedonopoulou, K. Yannakopoulou, D. Mentzafos, V. Lamzin,  A. Popov, and I. M. Mavridis,*  Acta Crystallogr.  2001, B57, 399-409.

  30. “Partial Thermal Dethreading of [3]pseudorotaxanes of α-Cyclodextrin with Linear Aliphatic α,ω-Aminoacids in Aqueous Solution.” Α. Tsortos, K. Yannakopoulou K. Eliadou, I. M. Mavridis, G. Nounesis,* J. Phys. Chem. Β, 2001, 105, 2664-2671.

  31. “Inclusion Compounds of Plant Growth Regulators in Cyclodextrins. Part II. Structure of the Complex of β-Cyclodextrin with β-Naphthyloxyacetic acid in solid state and in aqueous solution” A. Kokkinoua, K. Yannakopoulou, I.M. Mavridis, D. Mentzafos*, Carbohydr. Res.2001, 332, 85-94.

  32. Controlled Release of the Prays Oleae Pheromone, as a Consequence of Supramolecular Structure: Study of the Z-7-Tetradecenal/β-Cyclodextrin Complex in the Solid state and in Solution.” K. Yannakopoulou, J. A. Ripmeester, I. M. Mavridis*, J. Chem. Soc. Perkin 2, 2002, 1639-1644.

  33. "The Self-Association of the Drug Acemetacin and its Intermolecular Interactions and Stability with β-Cyclodextrin in Aqueous Solution. An NMR and HPLC Study" D. Zouvelekis, K.  Yannakopoulou,* A. Antoniadou-Vyza, I.M. Mavridis, Carbohydr. Res.,  2002, 337, 1387-1395.

  34. "NMR Spectral Assignment of Per-substituted Key-Intermediates of bCD and Implications in the Structures of the Derivatives" K. Eliadou, K. Yannakopoulou*, J. Inclus. Phenom. Macrocyclic. Chem., 2002, 44, 247.

  35. “Pseudorotaxanes of β-Cyclodextrin with Diamino End-functionalized Oligo-phenyl and -benzyl Compounds in Solution and in the Solid State” P. Giastas, N. Mourtzis, K. Yannakopoulou* and I. M. Mavridis*, J. Inclus. Phenom. Macrocyclic Chem., 2002, 44, 351.

  36. Molecular structures of the inclusion complexes β-Cyclodextrin/1,2-bis(4-aminophenyl)ethane and  β-Cyclodextrin/4,4’-diaminobiphenyl. Packing of dimeric β-Cyclodextrin inclusion complexes” P. Giastas, K. Yannakopoulou ,I. M. Mavridis* Acta Crystallogr.,  2003, B59, 287-299.

  37. “Rotaxanation of Congo Red into γ-Cyclodextrin. Solution Structures and Thermodynamic Parameters of 1:1 and 2:2 Adducts, as Obtained from NMR Spectroscopy and Microcalorimetry”  N. Mourtzis, G. Cordoyiannis, G. Nounesis, K. Yannakopoulou,* Supramolecular Chem., 2003, 15(7-8), 639-649.

  38. “Synthesis of 6-Mono-6-deoxy-β-cyclodextrins substituted with isomeric aminobenzoic acids.  Structural Characterization, Conformational Preferences and Self-inclusion, as Studied by NMR Spectroscopy in Aqueous Solution, and by X-Ray Crystallography in the Solid State.” K. Eliadou, P. Giastas, K. Yannakopoulou,*  I. M. Mavridis, J. Org. Chem., 2003, 68, 8550-8557.

  39. “Threading of long end-functionalized organic molecules into cyclodextrins:  structural analysis in aqueous solution by NMR spectroscopy and in the solid state by x-ray crystallography" K. Yannakopoulou,* I. M. Mavridis,* Curr. Org. Chem. (review article), 2004, 8(1), 25-34.

  40. " X-Ray Crystallography and Solution NMR Spectroscopy Characterization of heptakis(2,3-di-O-acetyl-6-bromo-6-deoxy)cyclomaltoheptaose@ P. Giastas,  K. Eliadou, Z. Plyta, K. Yannakopoulou,  and  I. M. Mavridis, Carbohydr. Res., 2004, 339/6, 1189-1194.

  41. "Influence of Host’s Substitution on the Orientation of the Guest: Pseudo-rotaxanes of Charged Cyclo­dextrins with Methyl Orange in Solution.” N. Mourtzis, K. Eliadou, K. Yannakopoulou,*  Supramolecular Chem. 2004,16 (8), 587–593.

  42. Positive Effect of Natural and Negatively Charged Cyclodextrins on the Stabilization of Penicillins towards β-Lactamase Degradation due to Inclusion and External Guest-Host Association. An NMR and MS Study”, Maffeo, D.; Leondiadis, L.; Mavridis, I. M.; Yannakopoulou K.* Org. Biomol. Chem., 2006, 4 (7), 1297-1304.

  43. Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "Receptor desmodynamic processes" S. De Luca, M. Saviano, L. Lassiani, Yannakopoulou K., P. Stefanidou, L. Aloj, G. Morelli, A. Varnavas, J. Med. Chem. 2006, 49 (8), 2456-2462.

  44. “Far-red luminescent ruthenium pyridylimine complexes; building blocks for multinuclear arrays”, A. C. G. Hotze, Faiz JA, N. Mourtzis, G. I. Pascu, P. R. A Webber, G. J. Clarkson, K. Yannakopoulou, Z. Pikramenou, M. J. Hannon, Dalton Trans 2006, (24): 3025-3034.

  45. "Partially Fluorinated, POSS-functionalized (meth)acrylate Resists for 193nm-bilayer Lithography". Antonios M. Douvas*, F. Van Roey, M. Goethals, K. Papadokostaki, K. Yannakopoulou, D. Niakoula, E. Gogolides, P. Argitis, Chem.  Mater., 2006, 18, 4040-4048.

  46. “Study of the solubility, antioxidant activity and structure of inclusion complex of vanillin with β-cyclodextrin” V. T. Karathanos,*, I. Mourtzinos, K. Yannakopoulou, N. K. Andrikopoulos, Food Chemistry, 2007, 101, 652-658.

  47. “Synthesis and characterization of per(6-guanidino-6-deoxy)cyclodextrins and studies of their  effect on DNA “,N. Mourtzis, K. Eliadou, C. Aggelidou, V. Sophianopoulou, I. M. Mavridis, K. Yannakopoulou*, Org. Biomol. Chem. 2007, 5, 125 - 131. Hot article

  48. "Encapsulation of olive leaf extract in β-Cyclodextrin I.Mourtzinos, F. Salta, K. Yannakopoulou, A. Chiou, V. T. Karathanos, J. Agric. Food Chem.  2007, 55, 8088-8094.

  49. "Crystal and Molecular Structure of Octakis(6-bromo-6-deoxy)-γ-cyclodextrin. A novel stacking of a distorted macrocycle” A. Paulidou, P. Giastas, N. Mourtzis, K.  Yannakopoulou, I.M. Mavridis Carbohydr, Res. 2007, 342(11), 1519-1524.

  50. “A novel packing of β-Cyclodextrin enclosing an unusual organization of guest: The inclusion complexes β-Cyclodextrin/4-pyridinealdazine” S. D. Chatziefthimiou, K. Yannakopoulou, I. M. Mavridis, Cryst. Eng. Commun. 2007,9, 976-979. Hot article.

  51. “Synthesis, characterisation, and remarkable biological properties of cyclodextrins bearing guanidino­alkylamino  and aminoalkylamino groups on their primary side”,  N. Mourtzis,  M. Paravatou,  I. M. Mavridis, M. L. Roberts, K. Yannakopoulou*, Chem. Eur. J. 2008, 14, 4188-4200.

  52. “Crystal structure of the inclusion complex of the antibacterial agent Triclosan in β-cyclodextrin and NMR study of its molecular encapsulation in positively and negatively charged cyclodextrins”, A. Paulidou, D. Maffeo, K. Yannakopoulou, I. M. Mavridis, Carbohydr. Res.2008, 343, 2634-2640.

  53. “Molecular Nanodevices based on Functionalized Cyclodextrins” , D. Velessiotis, D. Maffeo, E. Makarona, C. Viswanathan, K. Yannakopoulou, I. Mavridis, Z. Pikramenou, and N. Glezos,  Physica Status Solidi A 2008, 205 (11), 2532-2535.

  54. “Thermal stability of Hibiscus sabdariffa L. anthocyanins in the presence of β-cyclodextrin “ I. Mourtzinos, D. P. Makris, K. Yannakopoulou, N. Kalogeropoulos, I. Michali, V. T. Karathanos, J. Agric. Food Chem. 2008, 56, 10303–10310.

  55. “Binding of nucleotides and nucleosides to per(6-guanidino-6-deoxy)-cyclodextrins in solution” C. Aggelidou,  I. M. Mavridis, K. Yannakopoulou*, Eur. J. Org. Chem. 2009, 2299-2305.

  56. "Thermally-Induced Acid Generation from 18-Molybdodiphosphate and 18-Tungstodiphosphate within Poly(2-Hydroxyethyl Methacrylate) Films" A. Douvas, K. Yannakopoulou, P. Argitis, Chem. Mater., 2010, 22 (9): 2730-2740.

  57. “Similar modes of inclusion in complexes of β-cyclodextrin with sulfonylurea hypoglycemic drugs” A. Paulidou, D. Maffeo, K. Yannakopoulou, I. M. Mavridis, Cryst. Eng. Commun. 2010, 12 (2): 517-525

  58. Hydrolysis of glutaric anhydride to glutaric acid in the presence of β-cyclodextrin. Crystallographic and NMR study”,   A. Paulidou, K. Yannakopoulou, I. M. Mavridis* J. Incl. Phen. Macrocyclic Chem, 2010, 68, 297-303.

  59. Novel Polycarboxylated EDTA-Type Cyclodextrins as Ligands for Lanthanide Binding: Study of Their Luminescence, Relaxivity Properties of Gd(III) Complexes, and PM3 Theoretical Calculations”,   D. Maffeo, M. Lampropoulou, M. Fardis, Y. G. Lazarou, I. M. Mavridis, D. A.I. Mavridou, E. Urso, H. Pratsinis, D. Kletsas, K. Yannakopoulou*, Org. Biomol. Chem., 2010, 8, 1910-1921.

  60. “Polyphenol characterization and encapsulation in β-cyclodextrin of a flavonoid-rich Hypericum perforatum (St John's wort) extract “, N. Kalogeropoulos,* K. Yannakopoulou, A. Gioxari, A. Chiou, D. P Makris, LWT- Food Science and Technology, 2010, 43, 882-889.

  61. "Cooperative Heterodimer Formation Between Per-Guadinylated and Carboxylated or Phoshporylated Cyclodextrins in DMSO and DMSO-Water Studied by NMR Spectroscopy and Microcalorimetry”, Katerina Fotiadou, Angelos Thanassoulas, George Nounesis, K. Yannakopoulou*, Supramol. Chem., 2011, 23(17), 493-500.

  62. “Supramolecular Control of Photochromism in a β-Cyclodextrin/Schiff Base System”, E. Hadjoudis, K. Yannakopoulou, S. D. Hadjiefthimiou, A. Paulidou, I. M. Mavridis, J. Photochem. Photobiol. A: Chem. 2011, 217, 293-298.

  63. “Synthesis and characterisation of novel glycoclusters based on cell penetrating heptakis(6-aminoethylamino-6-deoxy)-β-cyclodextrin” M. Lampropoulou, K. Yannakopoulou, J. Incl. Phen. Macrocycl. Chem, 2011,70, 345-352 (DOI: 10.1007/s10847-010-9840-2.

  64. Real Time Monitoring of Nanomolar Binding To a Cyclodextrin Monolayer Immobilised on a Si/SiO2/Novolac Surface Using White Light Reflectance Spectroscopy: The Case of Triclosan”, D. Maffeo, Z. Velkov, K. Misiakos, K. Mergia,  A. Paulidou, M. Zavali, I. M. Mavridis, K. Yannakopoulou* J. Colloid. Interface Sci. 2011, 358, 369–375.

  65. “Symmetry requirements for the effective blocking of pore-forming toxins: Comparative study with α-, β-, and γ-cyclodextrin derivatives”, K. Yannakopoulou, L. Jicsinszky, C. Aggelidou, N. Mourtzis, T. M. Robinson, A. Yohannes, E. M. Nestorovich, S. Bezrukov4, V. A. Karginov, Antimicrob. Agents Chemother. (AAC), 2011, 55, 3594-3597.

  66. "Controlling the Stereospecificity of a Volume-Conserving Adiabatic Photoisomerization within a Nanotubular Self-Assembled Cage: A Reversible Light-Heat Torque Converter" G. Pistolis, A. Kaloudi-Chantzea,I. Balomenou, Ioanna, N. Karakostas, I.M. Mavridis, K.  Yannakopoulou, J. Phys.Chem. B 2011, 115 (36), 10665-10681. 

  67. Electronic transport between Au surface and STM tip via a multipodal cyclodextrin host - metallo-guest supramolecular system” , Lasse E. P. Kyllönen, Viswanathan Chinuswamy, Davide Maffeo, Evangelos T. Kefalas, Johanna M. Haider, Zoe Pikramenou, Irene M. Mavridis,  Konstantina Yannakopoulou,   Nikos Glezos, J. Phys. Org. Chem. 2012,  25, 198206.

  68. "Tamoxifen Subcellular Localization; Observation of Cell-specific Cytotoxicity Enhancement by Inhibition of Mitochondrial ETC Complexes I and III", T. A. Theodossiou, K. Yannakopoulou, C. Aggelidou and J. S. Hothersall, Photochem. Photobiol. 2012, 88(4), 1016-1022.

  69. "Cationic Cyclodextrins: Cell Penetrating Agents and Other Diverse Applications”, K. Yannakopoulou, J. Drug Del. Sci. Tech., 2012, 22 (3) 243-249 (review article).

  70. "S-Nitroso-β-Cyclodextrins as Novel Bimodal Carriers: Preparation, Detailed Characterization, Nitric Oxide Release and Molecular Encapsulation" L. Piras, T. A. Theodossiou, M. D. Manouilidou, S. Sortino, K. Yannakopoulou, Chem. Asian J. 2013, 8(11), 2768-2778 .

  71. A Multifunctional Bichromophoric Nanoaggregate for Fluorescence Imaging and Simultaneous Photogeneration of RNOS and ROS” A. Fraix, Antonio R. L. Gonçalves, V. Cardile, A. C. E. Graziano, T. A. Theodossiou, K. Yannakopoulou* and S. Sortino*, Chem. Asian J. 2013, 8(11), 2634-2641.

  72. "Protoporphyrin IX-β-Cyclodextrin Bimodal Conjugate: Nanosized Drug Transporter and Potent Phototoxin", C. Aggelidou, T. A. Theodossiou, K. Yannakopoulou, Photochem. Photobiol., 2013, 89, 1011-1019.

                                                                                           Book Chapter

Cyclodextrins” K.Yannakopoulou, I. M. Mavridis Invited Chapter in the Handbook "Cyclodextrins and their Complexes. Chemistry, Analytical Methods and Applications", H. Dodziuk, Ed., ISBN 3-527-31280-3 - Wiley-VCH, Weinheim, May 2006, pp. 356-367.

"Rotaxane and Catenane Structures Involving CyclodextrinsK.Yannakopoulou, I. M. Mavridis.Invited chapter in the Handbook "Cyclodextrins and their Complexes. Chemistry, Analytical Methods and Applications", H. Dodziuk, Ed., ISBN 3-527-31280-3 - Wiley-VCH, Weinheim, May 2006, pp. 356-367.


                                                                                    Popularized Publications

Konstantina Yannakopoulou & Irene M. Mavridis "Supramolecular chemistry of cyclodextrins and their applications" Pebtousia, Sept. 2000 in Greek (Κωνσταντίνα Γιαννακοπούλου, Ειρήνη Μαυρίδου «Η ΥΠΕΡΜΟΡΙΑΚΗ ΧΗΜΕΙΑ ΤΩΝ ΚΥΚΛΟΔΕΞΤΡΙΝΩΝ ΚΑΙ ΟΙ ΕΦΑΡΜΟΓΕΣ ΤΗΣ» Περιδικό «Πεμπτουσία» Τεύχος Σεπτεμβρίου 2000).


a.     Greek Patents

1.     “Νέες περι-6-γουανιδινο-, -αμινοαλκυλαμινο-, και -γουανιδινο­αλκυλαμινο- κυκλοδεξτρίνες, μέθοδοι σύνθεσής τους και χρήση τους στην συμπύκνωση  DΝΑ” Moύρτζης, Ν. ; Γιαννακοπούλου, Κ.; Ηλιάδου, K. ; Αγγελίδου, X.  Μαυρίδου Ε., Greek Patent 1004952, awarded July 28, 2005.

2.     EDTA-type cyclodextrin derivatives for metal ion binding and their complexes with gadolinium(IΙI) for use in magnetic resonance imaging K. Yannakopoulou, I. M. Mavridis, M. Fardis, D. Maffeo, M. Lampropoulou, Greek Patent No 10006924, priority date 28 Sept. 2009.

b. International Patents

“Per-6-guanidino-, -aminoalkylamino-and -guanidino-alkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of DNA and intracellular delivery” Κ. Υannakopoulou, I.M. Mavridis, N. Mourtzis, K. Eliadou, X. Aggelidou

1.             WO 2006027631  (A1)

2.             US   Patent: US7,834,174 B2, No. 11/662,450, Nov. 16,  2010

3.             European patent: ΕΡ05731803.2, Jan. 19, 2011-03-04