Laboratory of Structural & Supramolecular Chemistry

Dr. Irene Moustakali-Mavridis

Irene M. Mavridis studied at the National and Kapodistrian University of Athens, where she obtained the Degree of Chemistry in 1970. During 1969-1970, she worked as a post-graduate student in NRC “Demokritos” with C. Zioudrou in asymmetric synthesis. Subsequently she enrolled in the graduate program of Michigan State University, USA, where she earned a PhD in Physical Chemistry (1975) under the supervision of Professor Alexander Tulinsky. Her PhD Thesis title  is "The Structure Determination of 2-keto-3-deoxy-6-Phosphogluconate Aldolase (Pseudomonas Putida) at 3.5A Resolution". She joined the Institute of Physical Chemistry of NCSR “Demokritos” in 1976 and she directed the Laboratory of Structural and Supramolecular Chemistry till Oct 2011. During the years 1976, 1978, 1979-1980 and 1987 she has been a visiting research scientist at Michigan State University for time periods of 3-12 months. Her research interests include molecular structure and organization and structure-function correlations.


Thesis and Publications in Peer-Review Journals

  1. G. J. Karabatsos, C. Zioudrou and I. Moustakali, "Asymmetric Induction III. Effect of the t-butyl Group Directly bonded to the Carbonyl" Tetrahedron Let. (52), 5289-5292 (1972).

  2.  I. Moustakali and A. Tulinsky, "Structure of Copper(II) n-Propylporphine. Effect of a Metallo Substitution on a Free Base Macrocycle" J. Am. Chem. Soc. 95, 6811-6815 (1973).

  3. I. Moustakali-Mavridis, "The Structure Determination of 2-Keto-3-deoxy-6-phosphogluconic Aldolase from Pseudomonas Putida at 3.5 Å Resolution", Dissertation for the Degree of Doctor of Philosophy, Michigan State University (1975).

  4.  I. Moustakali-Mavridis and A. Tulinsky, "The Folding and Quaternary Structure of Trimeric 2-Keto-3-deoxy-6-phosphogluconic Aldolase at 3.5 Å Resolusion", Biochemistry 15, 4410-4417 (1976).

  5.  A. Mavridis and I. Moustakali-Mavridis, "Reinvestigation of Tolane" Acta Crystallog. B33, 3612-3615 (1977).

  6.  A. Tulinsky, I. Mavridis and R. F. Mann, "Expression of Functionality of α-Chymotrypsin” J. Biological Chem. 253, 1074-1078 (1978).

  7.  C. Zioudrou, I. Moustakali-Mavridis, P. Chrysochou and G. J. Karabatsos, "Asymmetric Induction V. Effect of R on Asymmetric Induction in Additions to abcC-COR Compounds" Tetrahedron 34, 3181-3186 (1978)

  8.  I. Moustakali-Mavridis, E. Hadjoudis and A. Mavridis, "Crystal and Molecular Structure of Some Thermochromic Schiff Bases", Acta Crystallog. B34, 3709-3715 (1978).

  9.  E. Hadjoudis, I. Moustakali-Mavridis and J. Xexakis, "Effect of Crystal and Molecular Structure on the Thermochromy and Photochromy of Some Salicylidene-2-aminopyridines", Israel J. of Chem. 18, 202-207 (1979).

  10.   I. Moustakali-Mavridis, E. Hadjoudis and A. Mavridis, "Crystal and Molecular Structure of Thermochromic Schiff Bases II. Structures of N-salicylidene-3-aminopyridine and N- (5-methoxy-salicylidene)-3-aminopyridine" Acta Cryst. B36, 1126-1130 (1980).

  11.   I. M. Mavridis, M. H. Hatada, A. Tulinsky and L. Lebioda, "The Structure of 2-Keto-3-deoxy-6-phosphogluconate Aldolase at 2.8A Resolution", J. Mol. Biol. 162, 419-444 (1982).

  12.   L. Lebioda, M. H. Hatada, A. Tulinsky and I. M. Mavridis, "Comparison of the Folding of 2-Keto -3-deoxy-6-phosphogluconate Aldolase, Triose Phosphate Isomerase and Pyruvate Kinase and its Implications in Molecular Evolution", J.  Mol. Biol. 162, 445-458 (1982).

  13.   E. Hadjoudis and I. Moustakali-Mavridis, "An Unusual Solid State Reaction Leading to the Photochromic N- (3,5-dichlorosalicylidene)-4-aminopyridine" Mol. Cryst. Liq. Cryst. 93, 61-72 (1983).  

  14.  I. M. Mavridis and E. Hadjoudis, "The Structure of the Hydrated Salt of 3,5-Dichlorosalicylaldehyde and 4-Aminopyridine", Acta Crystallogr. C39, 365-368 (1983).

  15.   E. Hadjoudis and I. Moustakali-Mavridis, "Structure Directing Effects in Heterocyclic Schiff Bases" Israel J. Chem. 25, 300-301 (1985).

  16.   E. Hadjoudis, M. Vittorakis and I. Moustakali-Mavridis, "Solid State Photochromism and Thermochromism of Salicylidene-2-thienylamines" Chemtronics 1, 58-63 (1986).

  17.   E. Hadjoudis, I. Moustakali-Mavridis, G. Tsoucaris and F. Villain, "Environmental Effects on Molecular Properties of Organic Compounds. Part I. The Formation of Inclusion Complexes of β-Cyclodextrin with Salicylidene-2-aminopyridine" Mol. Cryst. Liq. Cryst.134, 255-264 (1986).

  18.   E. Hadjoudis, M. Vitorakis and I. Moustakali-Mavridis, "Structural directing Effects in Solid State Organic Photochemistry" Mol. Cryst. Liq. Cryst.137, 1-15 (1986).

  19.   I. Moustakali-Mavridis, A. Terzis and E. Hadjoudis, "The Structure of N(-methoxysalisylidene)-2-thienylmethylamine", Acta Crystallogr. C43, 1389-1391 (1987).

  20.   I. Moustakali-Mavridis, A. Terzis and E. Hadjoudis, "The Structure of 2-Methoxy-N- (4-nitrobenzylidene)-5-Pyridylamine" Acta Crysallogr. C43, 1793-1795 (1987).

  21.   E. Hadjoudis, M. Vittorakis and I. Moustakali-Mavridis, "Photochromism and Thermochromism of Schiff Bases in the Solid State and in Rigid Glasses" Tetrahedron 43, 1345-1360 (1987).

  22.   I. Moustakali-Mavridis and E. Hadjoudis, "Structure of 2-Methoxy-N- (4-nitrobenzylidene)-5-pyridylamine II. Non Centrosymmetric Modification", Acta Crystallogr. C44, 1039-1041 (1988)

  23.   I. Moustakali-Mavridis and E. Hadjoudis, "The Crystal Structure of N-(4-nitrobenzylidene)-5-amino-2-methoxy pyridines", Mol. Cryst. Liq. Cryst, 156, 35-38 (1988).

  24.   E. Hadjoudis, I. Moustakali- Mavridis, G. Tsoucaris, F. Villain and G. Le Bas, "Environmental Effects on the Molecular Properties of the Organic Compounds. Part II. β-Cyclodextrin Inclusion Complexes with Cinnamic Acids", Mol. Cryst. Liq. Cryst. 156, 405-411 (1988).

  25.   E. Hadjoudis, I. Argyroglou and I. Moustakali-Mavridis, "Solid State Photochromism and Thermochromism of N-Salicylidene benzylamines and N-Salicylidene-2-thenylamines", Mol. Cryst. Liq. Cryst. 156, 39-48 (1988).

  26.   E. Hadjoudis and I. Moustakali-Mavridis, "Solid State Anil Photochromism", Mol. Cryst. Liq. Cryst. 186, 31-36 (1990).

  27.   Ε. Hadjoudis, I. Moustakali-Mavridis, J Zyss,. “Non-linear optics in Solid Schiffbases” in Conjugated Polymeric Materials: Oportunities in Electronics, Optoelectronics, and Molecular Electronics, Bredas, J. L., Chance, R. R., Eds.451-456, Kluwer Academic Publishers, 1990.

  28.   E. Hadjoudis, I. Argyroglou, E. Lambi and I. Moustakali-Mavridis, "Structural-Directing Effects in the Photochromism of Anils" Molecular Engineering 1, 67-74 (1991).

  29.   D. Mentzafos, I. M. Mavridis, G. Le Bas and G.Tsoucaris, "The Crystal Structure of the 4-tert-Butylbenzyl Alkohol β -Cyclodextrin Complex. Common Features in the Geometry of the β -cyclodextrin Dimeric Complexes", Acta Crystallogr. B47, 746-757 (1991).

  30.   I. M. Mavridis, E. Hadjoudis and G. Tsoucaris, "The Crystal Structure of the Inclusion Complex of Cyclomaltoheptaose (β -cyclodextrin) with 3,3-Dimethylbutylamine", Carbohydr. Res. 220, 11-21 (1991).

  31.   I. M. Mavridis and   E. Hadjoudis, "The Crystal Structure of the Inclusion Complex of Cyclomaltoheptaose (β -cyclodextrin) with 4-tert-Butyltoluene", Carbohydr. Res. 229, 1-15 (1992).

  32.   A. Rontoyianni, E. Hadjoudis and I. M. Mavridis, "Solid State Photochromism and Thermochromism of N-(5-bromo-salicylidene)-2-phenylethylamine", Mol. Cryst. Liq. Cryst. 242, 221-226 (1994).

  33.   G.Pistolis, E. Hadjoudis and I. M. Mavridis, "Photoactivity within Cyclodextrin Cavities: Inclusion Complexes of Anils with Cyclodextrins" Mol. Cryst. Liq.Cryst., 242, 215-219 (1994).

  34.   I. M. Mavridis, D. Mentzafos and H. Schenk, "Crystal Structure of the Heptakis (2,3,6-tri-O-methyl)-β-cyclodextrin Complex with Ethyldodecanoate Ester", Carbohydr. Res.253, 39-50 (1994).

  35.   A. Rontoyanni, I. M. Mavridis, E. Hadjoudis and A. J. M. Duisenberg, "The Crystal Structure of the Inclusion Complex of Cyclomaltoheptaose with 4-tert-Butylbenzoic acid", Carbohydr. Res. 252,19-32 (1994).

  36.   A. Rontoyanni and I. M. Mavridis, "The Crystal Structure of the inclusion Complex of Cyclomaltoheptaose (β -cyclodextrin ) with 3,5-Dimethylbenzoic Acid", J Inclus. Phenom. 18, 211-227 (1994).

  37.   I. Smonou, S. Khan, C. S. Foote, Y. Elemes, I. M. Mavridis, A. Pantidou, M. Orfanopoulos, "Reactions of Phenyltriazolinedione with Alkenes. Stereochemistry of the Methanol Adducts to Aziridinium Imine Intermediates", J. Am. Chem. Soc.117, 7081-7087 (1995). 

  38.  D. Mentzafos and I. M. Mavridis, “β -Cyclodextrin (Z)-9-Dodecen-1-ol 2:1 Complex”, Acta Crystallogr. C52, 1220-1223 (1996).

  39.   A. Rontoyanni and I. M. Mavridis, “β -Cyclodextrin Nonanoic Acid 1:1 Complex”, Acta Crystallogr., C52, 2277-2281 (1996)

  40.   K. Yannakopoulou, D. Mentzafos, I. M. Mavridis and K. Dandika, “Chiral Recognition of (R)-(_)-1,7-Dioxaspiro[5.5]undecane by Hexakis(2,3,6-tri-O-methyl)-α-Cyclodextrin”, Angew. Chem. Int. Ed. Engl. 35, 2480-2482 (1996).

  41.   Α. Rontoyianni and I. M. Mavridis, R. Israel, G. Beurskens, ‘The Crystal Structure of the Heptakis(2,3,6-tri-O-methyl)-ß-cyclodextrin with Methylcyclohexane’, J. Inclus. Phenom. 32, 415-428 (1998).

  42.   S. Makedonopoulou, I. M. Mavridis, K. Yannakopoulou, J. Papaioannou, ‘Organization of Long Aliphatic Monocarboxylic Acids in β-Cyclodextrin Channels. Crystal Structures of the Inclusion Complexes of Tridecanoic Acid and (Z)-tetradecenoic Acid in β-Cyclodextrin’, J. Chem. Soc. Chem. Commun., 2133-2134 (1998).

  43.   D. Mentzafos, I. M. Mavridis and K. Yannakopoulou, ‘Structure of Permethylated α-Cyclodextrin (R)-(_)-1,7-Dioxaspiro[5.5]undecane 1:1 Complex’, J.  Inclus. Phenom., 33, 321-330 (1999).

  44.   Α. Rontoyianni, I. M. Mavridis, ‘Dimeric Complex of Alpha-cyclodextrin with 1,12-Diaminododecane. Comparison with other Alpha Cyclodextrin Dimeric Complexes’, Supramol. Chem., 10, 213-218 (1999).

  45.   Κ. Eliadou, K. Yannakopoulou, A. Rontoyianni, I. M. Mavridis, ’NMR Detection of Simultaneous Formation of [2]- and [3]Pseudorotaxanes in Aqueous Solution between α-Cyclodextrin and Linear Aliphatic α,ω-Aminoacids, an α,ω-Diamine and an α,ω-Diacid of Similar Length, and Comparison with The Solid State Structures’,  J. Org. Chem. 64, 6217-6226 (1999).

  46.   S. Makedonopoulou, A. Tulinsky, I. M. Mavridis, ‘The Dimeric Complex of β-cyclodextrin with 1,13-tridecanedioic acid’, Supramol. Chem. 11, 73-81 (1999).

  47.   J. Papaioannou, N. Papadimitropoulos, I. M. Mavridis, ‘Dielectric Relaxation of β-Cyclodextrin Complex with 4-t-butyl-Benzyl Alkohol’, Mol. Phys. 97, 611-627( 1999).

  48.   E. Hadjoudis, I. M. Mavridis, T. Dziembowska, Z. Rozwadowski and R. Anulewicz, ‘Spectroscopic and Structural studies of the Thermochromism of Solid Di-anil of 2-Hydroxy-5-methyl-isophthalaldehyde’, Molecular Engineering 8, 97 (1999).

  49.   S. Makedonopoulou, J. Papaioannou, I. Argyroglou, I. M. Mavridis, “Crystal Structure of the Inclusion Complex of β-Cyclodextrin with the Aliphatic monoacids Tridecanoic Acid and (Z)-Tetradecenoic Acid. Formation of [3]Pseudorotaxanes”, J. Inclus. Phenom. Macrocycl. Chem., 36,191-215 (2000). Cover of the issue

  50.   S. Makedonopoulou, I. M. Mavridis, “Structure of the Inclusion Complex of β-Cyclodextrin with 1,12-Dodecanodioic Acid using Synchrotron Radiation Data. A Detailed dimeric β-Cyclodextrin Structure”, Acta Crystallogr., B56, 322-331 (2000).

  51.   S. Makedonopoulou, K. Yannakopoulou,  D. Mentzafos, V. Lamzin, A. Popov,  I. M. Mavridis, “Non-covalent Interactions in the Crystallization of the Enantiomers of 1,7-Dioxaspiro[5.5]undecane (Olive Fly Sex Pheromone) by Enantiospecific Cyclodextrin Hosts, Hexakis(2,3,6-tri-O-methyl)-α-cyclodextrin and Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin” Acta Crystallogr., B57, 399-409 (2001).

  52.   A. Kokkinou, K. Yannakopoulou, I. M. Mavridis, D. Mentzafos, “Inclusion Compounds of Plant Growth Regulators in Cyclodextrins. Part II. Structure of the Complex of β-Cyclodextrin with β-Naphthyloxyacetic acid in solid state and in aqueous solution” Carbohydr. Res., 332, 85-94 (2001).

  53.   A. Tsortos, K. Yannakopoulou, K. Eliadou, I.M. Mavridis and G. Nounesis, “Partial Thermal Dethreading of [3]pseudorotaxanes of α-Cyclodextrin with Linear Aliphatic α,ω-Aminoacids in Aqueous Solution”, J. Phys. Chem., B105, 2664-2667 (2001).

  54.   S. Makedonopoulou, I. M. Mavridis, “The dimeric complex of beta cyclodextrin with 1,14-tetradecanedioic acid. Comparison with related complexes”, Carbohydr. Res., 335, 213-220 (2001).

  55.   K. Yannakopoulou, J. A. Ripmeester, I. M. Mavridis, “Release of the Prays Oleae Pheromone, as a Consequence of Supramolecular Structure: Study of the β-Cyclodextrin/(Z)-7-Tetradecenal complex by X-ray crystallography and by NMR spectroscopy in the solid state and in solution” J. Chem. Soc. Perkin Trans. 2 1639-1644 (2002).

  56.   D. Zouvelekis, K. Yannakopoulou, I. M. Mavridis, E. Antoniadou-Vyza, The self-association of the drug acemethacin and its interactions and stabilization with β-cyclodextrin in aqueous solution as inferred from NMR spectroscopy and HPLC studies”, Carbohydr. Res., 337, 1387-1395 (2002).

  57.   J. C. Papaioannou, T. C. Ghikas, I. M. Mavridis, “Dielectric relaxationof the β-cyclodextrin complexes with tridecanoic acid and 1,13-tridecanedioic acid”, J.  Inclus. Phenom. Macrocycl. Chem., 43, 107-113 (2002).

  58.   N. C. Papandreou, S. Makedonopoulou, E. Antoniadou-Vyza, I. M. Mavridis, S. J. Hamodrakas, 2,4-Diamino-5-(1-naphthyl)-3,5-diaza-1-azoniaspiro [5.5]undeca-1,3-diene chloride” Acta Crystallogr. C58, 730-732 (2002).

  59.   P. Giastas, N. Mourtzis, K. Yannakopoulou and I. M. Mavridis, “Pseudorotaxanes of β-Cyclodextrin with Diamino End-functionalized Oligo-phenyl and -benzyl Compounds in Solution and in the Solid State”, J.  Inclus. Phenom. Macrocycl. Chem. 44, 247-250 (2002).

  60.   A. Salakhutdinov, D. N. Dalimov, T. F. Aripov, I. I. Tukfatullina, R. Kh. Ziyatdinova, A. Zh. Dzhuraev, F. G. Kamaev, L. Yu. Izotova, B. T. Ibragimov, I. Mavridis, and P. Giastas “Synthesis, Structure and Membrame Activity of New Glycyrretic Acid Dderivatives” Chemistry of Natural Compounds, 38, 249-256 (2002).

  61.   M. Yagi, S. Hirano, S. Yoyota, F. Toda, P. Giastas and I. M. Marvidis, “Photoreactions of  2- and 4-Pyridones in their Inclusion Crystal with a Host Compound”, J. Ηeterocyclic Chem. 59, 735-744 (2003).

  62.   P. Giastas, K. Yannakopoulou and I. M. Mavridis, “Molecular structures of the inclusion complexes β-Cyclodextrin/1,2-bis(4-aminophenyl)ethane and  β-Cyclodextrin/4,4΄-diaminobiphenyl. Packing of dimeric β-Cyclodextrin inclusion complexes”, Acta Crystallogr. B59, 287-299 (2003).

  63.   N. Pinotsis, D. D. Leonidas, E. D. Chrysina, N. G. Oikonomakos, I. M. Mavridis “The binding of beta and gamma-cyclodextrins to glycogen phosphorylase b: kinetic and crystallographic studies” Protein Sci. 12, 1914-1924 (2003). Cover of the issue

  64.   K. Eliadou, P. Giastas,  K. Yannakopoulou, I. M. MavridisSynthesis of 6-Mono-6-deoxy-β-cyclodextrins substituted with isomeric aminobenzoic acids.  Structural Characterization, Conformational Preferences and Self-inclusion, as Studied by NMR Spectroscopy in Aqueous Solution, and by X-Ray Crystallography in the Solid State”, J. Org. Chem. 68, 8550-8557 (2003).

  65.   K. Yannakopoulou and I. M. Mavridis “Threading of long end-functionalised organic molecules into cyclodextrins: Structural analysis in aqueous solution by NMR spectroscopy and in the solid state by X-ray crystallography”, Current Org. Chem. 8, 25-34 (2004). Invited review.

  66.   E. Hadjoudis  and I. M. Mavridis “Tautomerism by Hydrogen Transfer: the Case of Photochromic and Thermochromic Schiff-bases” Trends in Physical Chemistry, 9, 141-149 (2003). Invited review.

  67.  F. Toda, K. Yoshizawa, S. Hyoda, S. Toyota,  S. Chatziefthimiou, I. M. Mavridis, “Efficient Resolution of 2,2’-Dihydroxy-1,1’-binaphthyl by Inclusion Complexation with Chiral N-(3-Chloro-2-hydroxypropyl)-N,N,N-trimethylammonium Chloride”, Org. Biomol. Chem., 2, 449-451 (2004)

  68.   P. Giastas, K. Eliadou, Z. F. Plyta, K. Yannakopoulou, and I. M. MavridisStructural Characterization of Per-6-bromo-2,3-di-O-acetyl-β-cyclodextrin, Studied in Solution by NMR Spectroscopy and in the Solid State as a Methanol Complex by X-Ray Crystallography. Unsusual glucopyranose conformations in the crystal” Carbohydr. Res., 339, 1189-1194 (2004).

  69.   E. Hadjoudis, A. Rontoyianni, K. Ambroziak, T. Dziembowska, I. M. Mavridis “Photochromism and Thermochromism of Solid trans- N,N΄- bis-(salicylidene)-1,2-cyclohexanediamines and trans-N,N΄-bis-(2-hydroxynaphthylidene) )-1,2-cyclohexanediamine” J. Photochem. Photobiol. A: Chem. 162, 521-530 (2004).

  70.   Ε. Hadjoudis, I. M. Mavridis  “Photochromism and Thermochromism of Schiff Bases in the Solid State: Structural Aspects” Chem. Soc. Rev., 33, 579- 588 (2004). Invited review.

  71.   K. Yoshizawa, S. Toyota, F. Toda, S. Chatziefthimiou, P. Giastas, I. M. Mavridis, M. Kato “A Novel Control of Differential Inclusion Complexation in the Solid State by Seed Crystals” Angew. Chem. Int. Ed. 44, 5097-5100 (2005).

  72.   D. Maffeo, L. Leondiadis, I. M. Mavridis, K. Yannakopoulou “Positive Effect of Natural and Negatively Charged Cyclodextrins on the Stabilization of Penicillins towards β-Lactamase Degradation due to Inclusion and External Guest-Host Association. An NMR and MS Study”, Org. Biomol. Chem., 4, 1297 – 1304 (2006)

  73.  P. Zou, N. Pinotsis, S. Lange, Y-H. Song, A. Popov, I. Mavridis, O. M. Mayans, M. Gautel, M. Wilmanns “Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk” Nature, 439, 225-228 (2006).

  74.   P. Giastas, N. Pinotsis, G. Efthymiou, M. Wilmanns, P. Kyritsis, J- M. Moulis, I. M. Mavridis “The structure of the 2[4Fe-4S] ferredoxin from Pseudomonas aeruginosa at 1.32 Å resolution. Comparison with other high resolution structures of ferredoxins and contributing structural features to reduction potential values”, J. Biolog. Inorg. Chem. 11, 445-458 (2006).

  75.   S. D. Chatziefthimiou, Y. G. Lazarou, E. Hadjoudis, T. Dziembowska and I. M. Mavridis “Stable cis-Keto Forms of Salicylaldehyde Schiff Bases:Structural and Theoretical Aspects”, J. Phys Chem. B, 110, 23701-23709 (2006).

  76.   N. Mourtzis, K. Eliadou, C. Aggelidou, V. Sophianopoulou, I. M. Mavridis, K. Yannakopoulou, “Synthesis and characterization of per(6-guanidino-6-deoxy)cyclodextrins and studies of their  effect on DNA”, Org. Biomol. Chem. 5, 125-131 (2007).

  77.   A. Paulidou, P. Giastas, N. Mourtzis, K. Yannakopoulou, I. M. Mavridis “Crystal and Molecular Structure of Octakis(6-bromo-6-deoxy)-γ-cyclodextrin. A novel stacking of a distorted macrocycle”, Carbohydr. Res., 342, 1519-1524 (2007).

  78.   S. D. Chatziefthimiou, K. Yannakopoulou, I. M. Mavridis “β-Cyclodextrin trimers enclosing an unusual organization of guest: The inclusion complex β-Cyclodextrin/4-pyridinealdazine” Cryst. Eng. Comm. 9, 976-979 (2007).

  79.  N. Mourtzis, M. Paravatou, I. M. Mavridis, M. L. Roberts, K. Yannakopoulou Synthesis, characterisation, and remarkable biological properties of cyclodextrins bearing guanidino-alkylamino and aminoalkylamino groups on their primary side”, Chemistry-a European Journal, 14, 4188-4200 (2008).

  80.  A. Paulidou, D. Maffeo, K. Yannakopoulou, I M. Mavridis “Crystal structure of the inclusion complex of the antibacterial agent triclosan in β-cyclodextrin and NMR study of its molecular encapsulation in positively and negatively charged cyclodextrins” Carbohydr. Res., 343, 2634-2640 (2008).

  81.  D. Velessiotis, D. Maffeo, E. Makarona, C. Viswanathan, K. Yannakopoulou, I. Mavridis, Z. Pikra-menou, and N. Glezos “Molecular Nanodevices based on Functionalized Cyclodextrins”, Phys. Stat. Solid., 205, 2532-2535 (2008).

  82.  E. Hadjoudis, S. D. Chatziefthimiou, I. M. Mavridis, “Anils: Photochromism by H-transfer”, Current Org. Chem. 13, 269-286 (2009). Invited review

  83.  C. Aggelidou, I. M. Mavridis, K. Yannakopoulou “Binding of nucleotides and nucleosides to per(6-guanidino-6-deoxy)-cyclodextrins in solution”, Eur. J. Org. Chem., 2299-2305 (2009).

  84.  E. Saridakis, P. Giastas, G. Efthymiou,2 V. Thoma, J-M. Moulis, P. Kyritsis, I. M. Mavridis ”Insight into the protein and solvent contributions to the reduction potentials of [4Fe-4S]2+/+ clusters: Crystal structures of the Allochromatium vinosum ferredoxin variants C57A and V13G and the homologous Escherichia coli ferredoxin” J. Biolog. Inorg. Chem.14, 783-799 (2009).

  85.  A. Paulidou, D. Maffeo, K. Yannakopoulou, I.M. Mavridis Similar modes of inclusion in complexes of β-cyclodextrin with sulfonylurea hypoglycemic drugs” Cryst. Eng. Comm. 12, 517-525 (2010).

  86. D. Maffeo, M. Lampropoulou, M. Fardis, Y. G. Lazarou, I. M. Mavridis, D. A.I. Mavridou, E. Urso, H. Pratsinis, D. Kletsas, K. Yannakopoulou, “Novel Polycarboxylated EDTA-Type Cyclodextrins as Ligands for Lanthanide Binding: Study of Their Luminescence, Relaxivity Properties of Gd(III) Complexes, and PM3 Theoretical Calculations” , Org. Biomol. Chem. 8, 1910-1921 (2010).

  87.  A. Paulidou, K. Yannakopoulou, I. M. Mavridis, “Hydrolysis of glutaric anhydride to glutaric acid in the presence of β-cyclodextrin. Crystallographic and NMR study”, J Incl. Phenom. Macrocycl. Chem. 68, 297–303 (2010).

  88.  E. Hadjoudis, K. Yannakopoulou, S. D. Chatziefthimiou, A. Paulidou, I. M. Mavridis Supramolecular Control of Photochromism in a β-Cyclodextrin/Schiff Base System J Photochem. Photobiol. A: Chem. 217, 293–298 (2011).

  89.  D. Maffeo, Z. Velkov, K. Misiakos, K. Mergia, A. Paulidou, M. Zavali, I. M. Mavridis, K. YannakopoulouReal Time Nanomolar Detection of Triclosan Binding to an Amphiphilic Cyclodextrin Immobilised on a Surface using White Light Reflectometry J Colloid Interf. Sci. 358, 369-375 (2011).

  90.  L. E. P. Kyllönen, V. Chinuswamy, D. Maffeo, E. T. Kefalas, J. M. Haider, Z. Pikramenou, I. M. Mavridis, K. Yannakopoulou, N. GlezosElectronic transport between Au surface and STM tip via a multipodal cyclodextrin host - metallo-guest supramolecular system”, J Phys. Org. Chem., 25, 198206 (2012).

  91.  A I. Philippopoulos, E. Kolovou, N G. Tsierkezos, A. Paulidou, I. M. Mavridis, S. Batistatoud, E. BakeasSynthesis and characterization of the ruthenium(II) triphenylphosphine complex cis-[RuCl2(PPh3)2L] (L = 2-(2-pyridyl)quinoxaline ligand) for the catalytic hydrogenation of ketones Global J. Inorg. Chem., 2, 92-101 (2011).

  92.  I. Balomenou, A. Kaloudi-Chantzea, N. Karakostas, K. Yannakopoulou, I. M. Mavridis, G Pistolis "Controlling the Stereospecificity of a Volume-Conserving Adiabatic Photoisomerization within a Nanotubular Self-Assembled Cage: A Reversible Light_Heat Torque Converter", J Phys. Chem. B. 115, 10665-10681 (2011)

  93.   A. Boudjemline, E. Saridakis, M. J. Swann, L. Govada, I. M. Mavridis, N. E. Chayen "Use of Dual Polarisation Interferometry as a diagnostic tool for protein crystallisation", Anal. Chem. 83, 7881-7887 (2011).

  94.   J. R. Birtley, E. Saridakis, E. Stratikos, I. M. Mavridis "Crystal Structure of Human ER Aminopeptidase 2 Reveals Atomic Basis for Distinct Roles in Antigen Processing" Biochemistry, 51, 286–295 (2012)

  95.  N. Pinotsis, S. D. Chatziefthimiou, F. Berkemeier, F. Beuron, I. M. Mavridis, P. V. Konarev, D. I. Svergun, E. Morris, M. Rief, M. Wilmanns "Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties" PLoS Biol. Feb;10(2):e1001261 (2012).

  96. I. Evnouchidou, J. Birtley, S. Seregin, A. Papakyriakou, E. Zervoudi, M. Samiotaki, G. Panayotou, P. Giastas, O. Petrakis, D. Georgiadis, A. Amalfitano,  E. Saridakis, I. M. Mavridis, E. Stratikos “A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch that Leads to Altered Antigen Processing” J. Immunol. 189, 2383-2392 (2012).

  97. E. Zervoudi, E. Saridakis, J.R. Birtley, S. Seregin , E. Reeves, P. Kokkala, Y.A. Aldhamen, A. Amalfitano, I.M. Mavridis, E. James, D. Georgiadis and E. Stratikos (2013) “A rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses.” Proc. Natl. Acad. Sci. USA (2013), in press.

  98. N. Karakostas, I. M. Mavridis, K. Seintis, M. Fakis, E. N. Koini, I. D. Petsalakis, G. Pistoli "Highly efficient and unidirectional energy transfer within a tightly self-assembled host–guest multichromophoric array", Chem. Commun., in press.

Chapters in books

  1. E. Eliopoulos and I. M. Mavridis “Molecular Graphics Approaches in Structure Prediction and Determination”, in Crystallography of Supramolecular Compounds, Ed. G.Tsoucaris, J. L. Atwood and J. Lipkowski, NATO ASI, 480, 491-498, Kluwer Acad. Publ. (1996).

  2.  E. Eliopoulos and I. M. Mavridis, “An Interactive-Kinetic Approach to the Study of Supramolecular Structures”, in Crystallography of Supramolecular Compounds, Ed. G.Tsoucaris, J. L. Atwood and J. Lipkowski, NATO ASI, 480, 499-511, Kluwer Acad. Publ. (1996).

  3.   I. M. Mavridis, “Influence of the Guest on the Packing of Dimeric β-Cyclodextrin Complexes”, in Current Challenges on Large Supramolecular Assemblies, Ed. G. Tsoucaris, NATO ARW, Kluwer Acad. Publ., pp 393-403 (1999).

  4.  K. Yannakopoulou, and I. M. MavridisRotaxane and Catenane Structures Involving Cyclodextrins” Invited Chapter in the Handbook "Cyclodextrins and their Complexes. Chemistry, Analytical Methods and Applications", H. Dodziuk, Ed., p. 356-369, ISBN 3-527-31280-3 - Wiley-VCH, Weinheim, 2006.

  5. Irene M. MavridisStructural Characterization of Inorganic Biomaterials" in Biomedical Inorganic Polymers, W.E.G. Müller and H.C. Schöder Eds, Springer 2013, in press.


  1. "New Inclusion Complexes of Cyclodextrin , Process for their Preparation and their Use in Slow Release Formulation for the Treatment of Lepidopterous Pests" V. Mazomenos and I. M. Mavridis, European Patent No 92 401 709.8, 1992.

  2.  "Inclusion Complexes of Cyclodextrin and their Use in Slow Release Formulations for attracting Insects", V. Mazomenos and I. M. Mavridis, US Patent No US005650160A, 1997.

  3.  Per–6-guanidino-, -aminoalkylamino- and –guanidino­alkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of DNA and intracellular delivery, Υannakopoulou, Κ.; Mavridis, I. M.; Mourtzis, N.; Eliadou, K.; Aggelidou,Greek Patent 1004952,Sept. 10, 2004.

  4.  Per–6-guanidino-, -aminoalkylamino- andguanidino­alkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of DNA and intracellular delivery, Υannakopoulou, Κ.; Mavridis, I. M. European patent: ΕΡ05731803.2, Jan. 19, 2011-03-04.


  6. EDTA-type cyclodextrin derivatives for metal ion binding and their complexes with gadolinium(IΙI) for use in magnetic resonance imaging”, Κ. Υannakopoulou, , I. M. Mavridis, M. Fardis, D. Maffeo, M. Lambropoulou. Greek Patent application 20090100531, Sept 28, 2009.